PROTEINS

MMPs

S100s

SOD

IDPs

COPPER PROTEINS

OTHER PROTEINS

CUSTOM SERVICES

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READY-TO-USE NMR STANDARDS

Giotto Biotech has a strategic agreement with CortecNet that allows us to provide the NMR community with a number of NMR protein reference standards at very competitive prices. Solution and solid-state NMR standards are available, provided “ready-to-use” in tubes or pre-packed in rotors.

SOLUTION NMR	SOLID_STATE NMR

METABOLOMICS SERVICES

FOR THE BIOMEDICAL, PHARMACEUTICAL, AGRO-FOOD AND PROBIOTIC SECTORS

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NMR-BASED METABOLOMICS

Pairing the power of nuclear magnetic resonance (NMR) 
with the science of metabolomics to provide you with 
state-of-the-art services for your key applications 

Giotto Biotech, in collaboration with the FiorGen Foundation and the Magnetic Resonance Center (CERM) at the University of Florence, is in a unique position to provide you with metabolomics services thanks to access to top-of-the-line instrumentation (including a fully robotized 600 MHz NMR machine for high volumes, a 600 MHz HR-MAS, and an 850 MHz solid-state machine for metabolomics on tissue extracts). 

Some examples of the fields of application: 

• Biomedical: metabolomic profiling of biological fluids (breath condensate, expectorate, sweat, urine, blood, serum), disease fingerprinting 
• Pharmaceutical: prediction of drug toxicity, analysis of mechanism of action and side effects 
• Agro-food: analyses of food products (fruits, vegetables, dairy products, olive oil, meat and fish, etc.) 
• Probiotic: metabolomics of probiotic products for their characterization 

Advantages of metabolomics by NMR

As compared to metabolomics by mass spectrometry, metabolomics by NMR:

• is more accurate (though metabolomics by mass spectrometry is more sensitive)
• does not require the destruction of samples
• involves easier sample preparation
• is faster

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NMR ACCESS

Giotto Biotech provides NMR for structure determination, assignment, and screening.

A complete battery of NMR instrumentation (solution and solid state), ranging from 600 to 950 MHz, including an 850 MHz for solid-state, is available to meet the most disparate experimental conditions thanks to a close collaboration with the Interuniversity Consortium for Magnetic Resonance (CIRMMP), which also guarantees the quality of the services.

A preliminary HSQC is requested, or can be measured by us, to decide the quality of the spectra and the time required for the service.

Advanced LIMS are available to meet the needs of industry.

INFORMATION TECHNOLOGIES

Biological database development and management

• Customized databases tailored to specific projects
• Full database management: update, data entry interfaces, query

Database analysis

• Protein validation as therapeutic target or diagnostic marker
• Selection of putative protein ligands for drug discovery and drug development

Grid computing for structural biology

• Structure determination of target protein and target-ligand complexes, rational molecular design, prediction of binding affinities
• Molecular dynamics simulations to investigate the structure, dynamics, and thermodynamics of biological molecules and their complexes

SOLUTION NMR REFERENCE PROTEINS

Giotto Biotech has a strategic agreement with CortecNet that allows us to provide the NMR community with several NMR protein reference standards at very competitive prices. Solution NMR standards are available provided “ready-to-use” in tubes.
A wide range of selectively or uniformly labeled proteins produced in E. coli are available ranging from 6 kDa to 40 kDa molecular weight. Proteins are supplied in constricted NMR tubes sealed under argon for improved stability. The protein conformation is checked by NMR. 

Please don't hesitate to contact us if you can't find the labeling pattern you need!

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GB1  Giotto Biotech

Recombinant, from Streptococcus sp, folding state checked by NMR. residues 303-357 with the mutation T303Q MW = 6.2 kDa CAT # G03GB101 Technical details, prices and more ...

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SH3 - ALPHA-SPECTRIN  Giotto Biotech

Fom chicken, recombinant, folding state checked by NMR. residues 965-1025 MW = 7.2 kDa CAT # G99SH301 Technical details, prices and more ...

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Calbindin D9K  Giotto Biotech

Bovine, recombinant, folding state checked by NMR. residues 5-79 MW = 8.5 kDa CAT # G02CLB01 Technical details, prices and more ...

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Ubiquitin  Giotto Biotech

Human, recombinant, folding state checked by NMR. residues 1-76 MW = 8.5 kDa CAT # G03UBQ01 Technical details, prices and more ...

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MBP - Maltose Binding Protein  Giotto Biotech

Recombinant protein from E.Coli, folding state checked by NMR. residues 27-392 MW = 40.3 kDa CAT # G03MBP01 Technical details, prices and more ...

SOLID-STATE NMR REFERENCE PROTEIN

Giotto Biotech has a strategic agreement with CortecNet that allows us to provide the NMR community with several NMR protein reference standards at very competitive prices. solid-state NMR standards can be provided as bulk microcrystals or as “ready-to-use” packed in Bruker MAS rotors.

Please don't hesitate to contact us if you can't find the labeling pattern you need!

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fMLF  Giotto Biotech

Our new standard for ssNMR CAT # G20fMLF01cn Technical details, prices and more ...

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Ubiquitin  Giotto Biotech

Human, recombinant, folding state checked by NMR. residues 1-76 MW = 8.5 kDa CAT # G03UBQ01 Technical details, prices and more ...

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GB1  Giotto Biotech

Recombinant, from Streptococcus sp, folding state checked by NMR. residues 303-357 with the mutation T303Q MW = 6.2 kDa CAT # G03GB101 Technical details, prices and more ...