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DiscoverX TGFBR-1, active 14-912M

品牌：Eurofins DiscoverX

貨號(hào)：14-912M

規(guī)格：14-912M

貨期： DiscoverX

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品牌：DiscoverX 品名：TGFBR-1, active 貨號(hào)：14-912M 規(guī)格：250 μg

商品詳情參考文獻(xiàn) 相關(guān)資料

品牌：DiscoverX
品名：TGFBR-1, active
貨號(hào)：14-912M
規(guī)格：250 μg

簡(jiǎn)要說(shuō)明：

TGFBR-1, active

N-terminal GST-tagged recombinant, human TGFBR1 amino acids 200–end containing a T204D mutation. Transforming growth factor, beta receptor type I (TGF-beta receptor I) forms a heteromeric complex with TGF-beta receptor type II when bound to TGF-beta. This complex transduces the TGF-beta signal from the cell surface to the cytoplasm. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. TGF-beta receptor I is found in all tissues, but is most abundant in placenta and least abundant in brain and heart tissue. TGF-beta receptor I is phosphorylated at basal levels in the absence of ligand binding and is multiply phosphorylated, mainly in the GS region. Defects in TGF-beta receptor I are the cause of Loeys-Dietz syndrome type 1A (LDS1A), also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS).

產(chǎn)品介紹：

Target

TGFBR1

Expression System

Expressed by baculovirus in Sf21 insect cells

Application

Kinase Assay

Molecular Weight

62 kDa

Accession Number

NM_004612

Species

Human

Tag

GST

Purification Method

Glutathione agarose affinity chromatography

Content

Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

Storage

6 months at -70°C

Bulk Sizes

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