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DiscoverX PI3-Kinase (p110alpha(H1047R) p85alpha) 14-792-K

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DiscoverX PI3-Kinase (p110alpha(H1047R) p85alpha) 14-792-K

品牌：Eurofins DiscoverX

貨號：14-792-K

規(guī)格：14-792-K

貨期：DiscoverX

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品牌：DiscoverX 品名：PI3-Kinase (p110α(H1047R)/p85α) 貨號：14-792-K 規(guī)格：Bulk

商品詳情參考文獻相關資料

品牌：DiscoverX
品名：PI3-Kinase (p110α(H1047R)/p85α)
貨號：14-792-K

規(guī)格：Bulk

簡要說明：

PI3-Kinase (p110α(H1047R)/p85α)

Complex of N-terminal 6His-tagged recombinant, human p110α full length, containing the mutation H1047R, and untagged recombinant, human p85α full length. The H1047R substitution is a somatic mutation in p110α that has been associated with tumours of the colon, stomach, breast and brain. Combined in vitro and in vitro studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Samuels Y. et al., Science, (2004); 304: 554; Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).

產(chǎn)品介紹：

Target

PI3Kα/p85α

Expression System

Expressed by baculovirus in Sf21 insect cells

Application

Kinase Assay

Molecular Weight

125 kDa (p110α H1047R), 84 kDa (p85α)

Accession Number

U79143

Species

Human

Tag

6His

Purification Method

Ni2+/NTA-agarose

Content

Protein in 50mM Tris/HCl pH8.0, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1 mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.

Storage

6 months at -70°C

Bulk Sizes

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