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DiscoverX PI3-Kinase (p110alpha(E542K) p85alpha) murine 14-791M

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DiscoverX PI3-Kinase (p110alpha(E542K) p85alpha) murine 14-791M

品牌：Eurofins DiscoverX

貨號：14-791M

規(guī)格：14-791M

貨期：DiscoverX

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品牌：DiscoverX 品名：PI3-Kinase (p110α(E542K)/p85α) murine 貨號：14-791M 規(guī)格：250 μg

商品詳情參考文獻相關(guān)資料

品牌：DiscoverX
品名：PI3-Kinase (p110α(E542K)/p85α) murine
貨號：14-791M
規(guī)格：250 μg

簡要說明：

PI3-Kinase (p110α(E542K)/p85α) murine

Complex of N-terminal 6His-tagged recombinant, murine p110α full length, containing the mutation E542K, and untagged, recombinant, murine p85α full length. The E542K substitution is a somatic mutation in p110α that has been associated with tumours of the colon and brain. Combined in vitro and in vitro studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).

產(chǎn)品介紹：

Target

PI3Kα/p85α

Expression System

Expressed by baculovirus in Sf21 insect cells

Application

Kinase Assay

Molecular Weight

129 kDa (p110α E542K), 84 kDa (p85α)

Accession Number

BC089038

Species

Mouse

Tag

6His

Purification Method

Ni2+/NTA-agarose

Content

Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 0.2mM PMSF, 1mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.

Storage

6 months at -70°C

Bulk Sizes

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