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DiscoverX Abl (Y253F), active 14-759M

品牌：Eurofins DiscoverX

貨號(hào)：14-759M

規(guī)格：14-759M

貨期：DiscoverX

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品牌：DiscoverX 品名：Abl (Y253F), active 貨號(hào)：14-759M 規(guī)格：250 μg

商品詳情參考文獻(xiàn) 相關(guān)資料

品牌：DiscoverX
品名：Abl (Y253F), active
貨號(hào)：14-759M
規(guī)格：250 μg

簡(jiǎn)要說明：

Abl (Y253F), active

N-terminal 6His-tagged recombinant, human Abl, amino acids 27-end containing the Y253F mutation. The Abl tyrosine kinase inhibitor STI571 is an effective therapy for stable-phase chronic myeloid leukemia patients. Many patients responding to STI571 later relapse due to a reactivation of Bcr-Abl activity. In certain cases this appears to correlate with the presence of the Y253F mutation, which confers resistance to drug binding (Shah et al., (2002), Cancer Cell 2, 117-125).

產(chǎn)品介紹：

Target

Abl

Expression System

Expressed by baculovirus in Sf21 insect cells

Application

Kinase Assay

Molecular Weight

121 kDa

Accession Number

U07563

Species

Human

Tag

6His

Purification Method

Ni2+/NTA-agarose

Content

Protein in 50mM Tris/HCl pH7.5, 150mM NaCl, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.03% Brij 35. Frozen solution.

Storage

6 months at -70°C

Bulk Sizes

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