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DiscoverX Abl (Q252H), active 14-751

品牌：Eurofins DiscoverX

貨號：14-751

規(guī)格：14-751

貨期：DiscoverX

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品牌：DiscoverX 品名：Abl (Q252H), active 貨號：14-751 規(guī)格：10 μg

商品詳情參考文獻(xiàn) 相關(guān)資料

品牌：DiscoverX
品名：Abl (Q252H), active
貨號：14-751
規(guī)格：10 μg

簡要說明：

Abl (Q252H), active

N-terminal 6His-tagged recombinant, human Abl, amino acids 27-end containing the Q252H mutation. The Abl tyrosine kinase inhibitor STI571 is an effective therapy for stable-phase chronic myeloid leukemia patients. Many patients responding to STI571 later relapse due to a reactivation of Bcr-Abl activity. In certain cases this appears to correlate with the presence of the Q252H mutation, which confers resistance to drug binding (Shah et al., (2002), Cancer Cell 2, 117-125).

產(chǎn)品介紹：

Target

Abl

Expression System

Expressed by baculovirus in Sf21 insect cells

Application

Kinase Assay

Molecular Weight

121 kDa

Accession Number

NM_005157.3; NM_007313.2

Species

Human

Tag

6His

Purity

Purity 51% by SDS-PAGE and Coomassie staining.

Purification Method

Ni2+/NTA-agarose

Content

Protein in 50 mM Tris/HCl pH7.5, 150 mM NaCl, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1 mM EGTA, 0.1% 2-mercaptoethanol, 0.03% Brij 35. Frozen solution.

Storage

6 months at -70°C

Bulk Sizes

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