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DiscoverX Abl (H396P), active 14-750-K

品牌：Eurofins DiscoverX

貨號(hào)：14-750-K

規(guī)格：14-750-K

貨期：DiscoverX

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品牌：DiscoverX 品名：Abl (H396P), active 貨號(hào)：14-750-K 規(guī)格：Bulk

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品牌：DiscoverX
品名：Abl (H396P), active
貨號(hào)：14-750-K
規(guī)格：Bulk

簡(jiǎn)要說明：

Abl (H396P), active

N-terminal 6His-tagged recombinant, human Abl, amino acids 27-end containing the H396P mutation. The Abl tyrosine kinase inhibitor STI571 (Gleevec?) is an effective therapy for stable-phase chronic myeloid leukemia patients. Many patients responding to STI571 later relapse, due to a reactivation of Bcr-Abl activity. In certain cases this appears to correlate with the presence of the H396P mutation, which confers resistance to drug binding due to steric interference. (Corbin AS. et al, Blood, (2002); 101:4611-4614 and La Rosee P. et al, Cancer Research; 62:7149-7153).

產(chǎn)品介紹：

Target

Abl

Expression System

Expressed by baculovirus in Sf21 insect cells

Application

Kinase Assay

Molecular Weight

121 kDa

Accession Number

U07563

Species

Human

Tag

6His

Purification Method

Ni2+/NTA-agarose

Content

Protein in 50mM Tris/HCl pH7.5, 150mM NaCl, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.03% Brij 35. Frozen solution.

Storage

6 months at -70°C

Bulk Sizes

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