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DiscoverX CHK2 (I157T), active 14-741M

品牌：Eurofins DiscoverX

貨號(hào)：14-741M

規(guī)格：14-741M

貨期：DiscoverX

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品牌：DiscoverX 品名：CHK2 (I157T), active 貨號(hào)：14-741M 規(guī)格：250 μg

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品牌：DiscoverX
品名：CHK2 (I157T), active
貨號(hào)：14-741M
規(guī)格：250 μg

簡(jiǎn)要說(shuō)明：

CHK2 (I157T), active

N-terminal GST and C-terminal 6His-tagged,.recombinant human CHK2, amino acids 5-end, containing the I157T mutation. Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells.

產(chǎn)品介紹：

Target

CHK2

Expression System

Expressed in E. coli

Application

Kinase Assay

Molecular Weight

89.6 kDa

Accession Number

NM_007194

Species

Human

Tag

GST, 6His

Purification Method

Glutathione agarose affinity chromatography; Ni2+/NTA agarose

Content

Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

Storage

1 year at -70°C

Bulk Sizes

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