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DiscoverX FGFR1 (V561M), active 14-734-K

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DiscoverX FGFR1 (V561M), active 14-734-K

品牌：Eurofins DiscoverX

貨號：14-734-K

規(guī)格：14-734-K

貨期：DiscoverX

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品牌：DiscoverX 品名：FGFR1 (V561M), active 貨號：14-734-K 規(guī)格：Bulk

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品牌：DiscoverX
品名：FGFR1 (V561M), active
貨號：14-734-K
規(guī)格：Bulk

簡要說明：

FGFR1 (V561M), active

N-terminal GST-tagged recombinant, human FGFR1 amino acids 456 - 765 containing the V561 mutation. The coordinates for recombinant human FGFR1 were described in Homann et al. (2001). Blencke et al. (2004) suggested mutations to a conserved threonine residue at the ATP binding site would result in inhibitor resistance. The amino acid valine 561 was mutated to a methionine in FGFR1 which corresponded to previously reported mutations found in Abl (T315) and EGFR (T766) which had been shown to confer resistance to selective inhibitors. Assay data for FGFR1 V561M had shown that this mutation had conferred resistance to PP58 (pyrido [2,3-d] pyrimidine tyrosine kinase inhibitor) compared to that of the wild type.

產(chǎn)品介紹：

Target

FGFR1

Expression System

Expressed by baculovirus in Sf21 insect cells

Application

Kinase Assay

Molecular Weight

62.3 kDa

Species

Human

Tag

GST

Purification Method

Glutathione agarose affinity chromatography

Content

Protein in 50mM Tris/HCl pH 7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij 35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.

Storage

6 months at -70°C

Bulk Sizes

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