Shiga-like toxin (verotoxin) is a toxin produced by some strains of Escherichia coli. Shiga-like toxin is named for its similarity to the AB5-type Shiga toxin produced by the bacteria Shigella dysenteriae. There are two known types-SLT1 and SLT2. The Shiga-like toxin is linked with hemolytic-uremic syndrome. Shiga-like toxin requires highly specific receptors on the cells'' surface in order to attach and enter the cell. Species such as cattle, swine, and deer which do not carry these receptors may harbor toxigenic bacteria without any ill effect, dropping them in their feces, from where they may be distributed to humans. Shiga Like Toxin-1 Subunit B has nontoxic action, it is the functional region which binds to the receptor. The Shiga Like Toxin-1 Subunit B can be useful in vaccine study, antibody test and other functional research.
Mouse antibody Monoclonal.
Shiga like toxin 1B monoclonal antibody IgG1 derived from mouse, immunized with recombinant Shiga-like toxin 1 subunit B ( E. coli O157:H7). The subunit B has nontoxic action and is a functional region which binds to the receptor. Shiga-like toxin 1 subunit B contains amino acid from 2 to 90 of Shiga-like toxin 1subunit B, it forms pentamer binding to the host cell receptor.
Sterile Filtered clear colorless solution.
1x PBS pH-7.4 + 0.1% sodium azide.?.
Shiga like toxin 1B monoclonal antibody although stable at 4°C for 1 week, should be stored below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Greater than 95% as determined by 12% PAGE (coomassie staining).
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