Catalogue number
ANT-265
Synonyms
p50, Bp50, CDW40, MGC9013, TNFRSF5, CD40.
Type
Mouse Anti Human Monoclonal.
Introduction
CD40 is part of the TNF-receptor superfamily. CD40 is a necessary mediator for vast range of immune and inflammatory responses together with T cell-dependent immunoglobulin class switching, memory B cell growth, and germinal center formation. The transcription factor AKNA regulates the expression of CD40 and its ligand, which is vital for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand is crucial for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is the receptor for TNFSF5/CD40L.
Clone
hCD40.
Immunogen
Activated Human B cells.
Ig Subclass
Mouse IgG1.
Purification Method
Protein-A.
Formulation
1mg/ml in PBS (after reconstitution).
Storage Procedures
Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
Solubility
Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Applications
Staining antibody. For staining, use 10μl/1,000,000 cells.
Available Conjugates
This
antibody is also available unconjugated and conjugated to Biotin. For staining with biotin or FITC-conjugated
antibody use 5-10μl/106 cells.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
