Catalogue number
PRO-1685
Synonyms
Zinc finger protein 346, JAZ, Zfp346, ZNF346.
Introduction
ZNF346 is a nucleolar, zinc finger protein which specially binds to double-stranded RNA or RNA/DNA fusions, instead of DNA alone. Zinc finger domains vital for dsRNA binding and essential for its nucleolar localization. ZNF346 takes part in cell growth and survival.
Description
ZNF346 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 317 amino acids (1-294) and having a molecular mass of 35.3 kDa.
ZNF346 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
The ASCC1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMEYPAPA TVQAADGGAA GPYSSSELLE GQEPDGVRFD RERARRLWEA VSGAQPVGRE EVEHMIQKNQ CLFTNTQCKV CCALLISESQ KLAHYQSKKH ANKVKRYLAI HGMETLKGET KKLDSDQKSS RSKDKNQCCP ICNMTFSSPV VAQSHYLGKT HAKNLKLKQQ STKVEALHQN REMIDPDKFC SLCHATFNDP VMAQQHYVGK KHRKQETKLK LMARYGRLAD PAVTDFPAGK GYPCKTCKIV LNSIEQYQAH VSGFKHKNQS PKTVASSLGQ IPMQRQPIQK DSTTLED.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
