Catalogue number
CYT-880
Synonyms
CD70 Molecule, TNFSF7, CD27L, Tumor Necrosis Factor
(Ligand) Superfamily, Member 7, Tumor Necrosis Factor Ligand Superfamily Member
7, CD70 Antigen, CD27 Ligand, CD27LG, CD27-L, Surface Antigen CD70, Ki-24
Antigen, CD70 antigen.
Introduction
CD70 also known as TNFSF7 is a cytokine which binds to CD27. TNFSF7
takes part in T-cell activation as well as induces the proliferation of
costimulated T-cells. Moreover, TNFSF7 enhances the generation of cytolytic
T-cells. Among the diseases which are associated with TNFSF7: Include acute
myocarditis & Myocarditis.
Description
TNFSF7 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 178 amino acids (39-193 a.a) and
having a molecular mass of 19.5kDa.
TNFSF7 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile filtered colorless solution.
Formulation
TNFSF7 protein solution (1mg/ml) containing 20mM Tris-HCl
buffer (pH 8.0) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 80% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH
SSGLVPRGSH MGSQRFAQAQ
QQLPLESLGW DVAELQLNHT GPQQDPRLYW QGGPALGRSF LHGPELDKGQ LRIHRDGIYM VHIQVTLAIC
SSTTASRHHP TTLAVGICSP ASRSISLLRL SFHQGCTIAS QRLTPLARGD TLCTNLTGTL LPSRNTDETF
FGVQWVRP.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
