Catalogue number
PRO-2264
Synonyms
CUB
Domain Containing Protein 1, Subtractive Immunization M Plus HEp3-Associated
135 KDa Protein, Transmembrane And Associated With Src Kinases, Membrane
Glycoprotein Gp140, SIMA135, TRASK, CD318 Antigen, CD318, CUB domain-containing
protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus
HEp3-associated 135 kDa protein, Transmembrane and associated with src kinases.
Introduction
CUB Domain Containing Protein 1, also known as CDCP1 is a transmembrane
protein which contains three extracellular CUB domains. CDCP1 is implicated in
cell adhesion and cell matrix association. In addition, CDCP1 takes part in the
regulation of anchorage versus migration or proliferation versus
differentiation through its phosphorylation. CDCP1 is also a novel marker for leukemia
diagnosis as well as for immature hematopoietic stem cell subsets. Furthermore,
the extracellular region of human CDCP1 shares amino acid identity sequence
with the mouse CDCP1.
Description
CDCP1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 646 amino acids (30-667a.a.) and having a molecular mass of 72.8kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). CDCP1 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Source
Sf9,
Baculovirus cells.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
CDCP1
protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and
10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Amino acid sequence
FEIALPRESN
ITVLIKLGTP TLLAKPCYIV ISKRHITMLS IKSGERIVFT FSCQSPENHF VIEIQKNIDC MSGPCPFGEV QLQPSTSLLP
TLNRTFIWDV KAHKSIGLEL QFSIPRLRQI GPGESCPDGV THSISGRIDA TVVRIGTFCS NGTVSRIKMQ
EGVKMALHLP WFHPRNVSGF SIANRSSIKR LCIIESVFEG EGSATLMSAN YPEGFPEDEL MTWQFVVPAH
LRASVSFLNF NLSNCERKEE RVEYYIPGST TNPEVFKLED KQPGNMAGNF NLSLQGCDQD AQSPGILRLQ
FQVLVQHPQN ESNKIYVVDL SNERAMSLTI EPRPVKQSRK FVPGCFVCLE SRTCSSNLTL TSGSKHKISF
LCDDLTRLWM NVEKTISCTD HRYCQRKSYS LQVPSDILHL PVELHDFSWK LLVPKDRLSL VLVPAQKLQQ
HTHEKPCNTS FSYLVASAIP SQDLYFGSFC PGGSIKQIQV KQNISVTLRT FAPSFQQEAS RQGLTVSFIP
YFKEEGVFTV TPDTKSKVYL RTPNWDRGLP SLTSVSWNIS VPRDQVACLT FFKERSGVVC QTGRAFMIIQ
EQRTRAEEIF SLDEDVLPKP SFHHHSFWVN ISNCSPTSGK QLDLLFSVTL TPRTVDLTLE HHHHHH.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
