Catalogue number
CYT-860
Synonyms
Fibroblast Growth Factor Binding Protein 1, FGFBP, HBP17,
17 KDa Heparin-Binding Growth Factor-Binding Protein, 17 KDa HBGF-Binding
Protein, FGF-Binding Protein 1, FGF-BP1, FGFBP-1, FGF-BP, Heparin-Binding
Growth Factor Binding Protein, Fibroblast Growth Factor-Binding Protein 1, Fibroblast
growth factor-binding protein 1.
Introduction
Fibroblast Growth Factor Binding Protein 1, also known as FGFBP1 is a
secreted fibroblast growth factor carrier protein. FGFBP1 plays a vital part in
cell proliferation, differentiation and migration by binding to fibroblast
growth factors and potentiating their biological effects on target cells. In
addition, FGFBP1 also takes part in tumor growth as an angiogenic switch
molecule, furthermore an expression of FGFBP1 has been associated with more than a few types of cancer as well
as pancreatic and colorectal adenocarcinoma.
Description
FGFBP Human Recombinant produced in E.Coli is a single, non-glycosylated
polypeptide chain containing 234 amino acids (24-234 a.a) and having a
molecular mass of 26.2kDa.
FGFBP is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered colorless clear solution.
Formulation
FGFBP protein solution (0.25mg/ml) containing Phosphate
buffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH
SSGLVPRGSH MGSKKKVKNG
LHSKVVSEQK DTLGNTQIKQ KSRPGNKGKF VTKDQANCRW AATEQEEGIS LKVECTQLDH EFSCVFAGNP
TSCLKLKDER VYWKQVARNL RSQKDICRYS KTAVKTRVCR KDFPESSLKL VSSTLFGNTK PRKEKTEMSP
REHIKGKETT PSSLAVTQTM ATKAPECVED PDMANQRKTA LEFCGETWSS LCTFFLSIVQ DTSC.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.
