Catalogue number
PRO-501
Synonyms
Protein C-ets-1, ETS-1, p54, ETS1, EWSR2, FLJ10768.
Introduction
The proto-oncogene c-Ets-1 is a transcription factor known to regulate expression of a number of genes involved in extracellular matrix remodeling, control numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. Ets-1 interacts with the urokinase-type plasminogen activator gene enhancer and with the promoters of stromelysins-1 and collagenase-1 gene which may implicate it in this process.
The conserved ETS domain inside these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes.
Description
ETS1 Human Recombinant (aa 220-442) expressed in E.coli, shows a 48 kDa band on SDS-PAGE (Including GST).
The ETS1 is purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
ETS1 protein in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Stability
Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.
Applications
? ELISA
? Inhibition Assays
? Western Blotting.
Safety Data Sheet
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
