Catalogue number
PRO-1885
Synonyms
Melanoregulin, DSU, Dilute Suppressor Protein Homolog, WDT2,
Whn-Dependent Transcript 2.
Introduction
Melanoregulin
(MREG) takes part in membrane fusion and in regulating the biogenesis of disk
membranes of photoreceptor rods. MREG is expressed in photoreceptor cells as
two isoforms as a result of alternative splicing. MREG interacts with
Peripherin-2, a photoreceptor specific tetraspanin protein which is required to
preserve normal cell structure during the renewal process of membrane fusion.
Moreover, MREG plays a part in the incorporation of pigments into hair.
Description
MREG Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 237 amino acids (1-214 a.a) and
having a molecular mass of 27.3kDa.
MREG is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
MREG protein solution (0.5mg/ml) containing 20mM Tris-HCl
buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater
than 90% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMGLRDWL RTVCCCCGCE CLEERALPEK EPLVSDNNPY SSFGATLVRD
DEKNLWSMPH DVSHTEADDD RTLYNLIVIR NQQAKDSEEW QKLNYDIHTL RQVRREVRNR WKCILEDLGF
QKEADSLLSV TKLSTISDSK NTRKAREMLL KLAEETNIFP TSWELSERYL FVVDRLIALD AAEEFFKLAR
RTYPKKPGVP CLADGQKELH YLPFPSP
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
