Caused by one of four closely related virus serotypes of the genus Flavivirus, family Flaviviridae, each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. In cell culture experiments and mice Morpholino antisense oligos have shown specific activity against Dengue virus.
Polyvalent dengue antigen is a 22kDa protein that contains 4 dengue antigen subtypes, produced in E.coli and fused to a 6xHis Tag. The immunoreactive peptide span from the viral envelope to the non-functional region. The polyvalent dengue antigen consists of 25% recombinant antigen from each of the dengue subtypes in their composition. The Polyvalent dengue antigen detects all four dengue subtypes. The sensitivity and specificity could reach approximately 93% and 96% in dengue IgG and IgM ELISA assay.
Escherichia Coli.
Purified by proprietary chromatographic technique.
Protein is >95% pure as determined by 12% PAGE (coomassie staining).
Polyvalent Dengue although stable at 4°C for 1 week, should be stored below -18°C.?
Please prevent freeze thaw cycles.
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