Catalogue number
ENZ-910
Synonyms
Peroxiredoxin-2, Prdx2, Prdx, Thiol-specific antioxidant
protein, TSA, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide
reductase 1.
Introduction
PRDX2 is part of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. PRDX2 takes part as an antioxidant protective role in cells, and contributes to the antiviral activity of CD8(+) T-cells. PRDX2 has proliferative effect in cancer development or progression.
If PRDX2 protection is insufficient against peroxidases, the DNA damage results in neurological disease such as Alzheimer's or DNA damage leading to cancer.
Description
PRDX2 Rat Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 222 amino acids (1-198 a.a) and
having a molecular mass of 24.3kDa.
PRDX2 is fused to a 24 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
PRDX2
protein solution (1mg/ml) containing Phosphate Buffered Saline (pH 7.4), 10%
glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSHMASGNA HIGKPAPDFT GTAVVDGAFK EIKLSDYRGK YVVLFFYPLD
FTFVCPTEII AFSDHAEDFR KLGCEVLGVS VDSQFTHLAW INTPRKEGGL GPLNIPLLAD VTKSLSQNYG
VLKNDEGIAY RGLFIIDAKG VLRQITVNDL PVGRSVDEAL
RLVQAFQYTD EHGEVCPAGW KPGSDTIKPN VDDSKEYFSK HN.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
