Catalogue number
PRO-2219
Synonyms
Serine Peptidase Inhibitor, Kunitz Type, 2, Placental
Bikunin, Hepatocyte Growth Factor Activator Inhibitor Type 2, Serine Protease
Inhibitor, Kunitz Type, 2, HAI-2, HAI2, Kop, Kunitz-Type Protease Inhibitor 2, Placental,
Bikunin, DIAR3, PB, Kunitz-type protease inhibitor 2.
Introduction
| SPINT2 is a transmembrane protein acts as an inhibitor of HGF activator. SPINT2 inhibits plasmin, plasma and tissue kallikrein, and factor XIa. SPINT2 has two extracellular Kunitz domains that inhibit few serine proteases. SPINT2 is assumed tumor suppressor, mutations in SPINT2 leads to a congenital sodium diarrhea. |
Description
SPINT2 produced in Sf9 Baculovirus cells is a single,
glycosylated polypeptide chain containing 176 amino acids (28-197 a.a.) and
having a molecular mass of 20kDa. (Molecular size on SDS-PAGE will appear at
approximately 18-28kDa).
SPINT2 is expressed with a 6 amino acid His tag at
C-Terminus and purified by proprietary chromatographic techniques.
Source
Sf9,
Baculovirus cells.
Physical Appearance
Sterile Filtered clear solution.
Formulation
SPINT2 protein solution (0.2mg/ml) contains phosphate
buffered saline (pH 7.4) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 80.0% as determined by SDS-PAGE.
Amino acid sequence
ADRERSIHDF
CLVSKVVGRC RASMPRWWYN VTDGSCQLFV YGGCDGNSNN YLTKEECLKK CATVTENATG DLATSRNAAD
SSVPSAPRRQ DSEDHSSDMF NYEEYCTANA VTGPCRASFP RWYFDVERNS CNNFIYGGCR GNKNSYRSEE
ACMLRCFRQQ ENPPLPLGSK HHHHHH.
Safety Data Sheet
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
