Catalogue number
PRO-2255
Synonyms
C1q/MBL/SPA
receptor, C1qR(p), C1qRp, Cell surface antigen AA4, Complement, component 1 q
subcomponent receptor 1, Lymphocyte antigen 68, Ly-68, CD93, Cd93.
Introduction
CD93, is a receptor or else an element of a larger receptor complex for
C1q, MBL2-mannose-binding lectin and SPA-pulmonary surfactant protein A. CD93 mediates the enhancement of phagocytosis in monocytes as well as
macrophages upon interaction with soluble defense collagens. CD93 takes part in the intercellular adhesion.
Furthermore, CD93 was expressed on (pre) plasmablasts/plasma cells, including long-lived plasma cells which demonstrated decreased
cell cycle activity, high levels of isotype-switched Ig secretion, as well as
modification of the transcriptional network. CD93 is vital for the maintenance
of plasma cells in bone marrow niches.
Description
CD93 produced in Sf9
Insect cells is a single, glycosylated polypeptide chain containing 558 amino
acids (23-572a.a.) and having a molecular mass of 60.1kDa. (Molecular size on
SDS-PAGE will appear at approximately 70-100kDa).
CD93 is expressed with
an 8 amino acid His tag at C-Terminus and purified by proprietary
chromatographic techniques.
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Source
Sf9,
Insect cells.
Physical Appearance
Sterile
filtered colorless solution.
Formulation
CD93
protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10%
glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater
than 95.0% as determined by SDS-PAGE.
Amino acid sequence
ADSQAVVCEG TACYTAHWGK LSAAEAQHRC NENGGNLATV KSEEEARHVQ QALTQLLKTK APLEAKMGKF WIGLQREKGN CTYHDLPMRG FSWVGGGEDT AYSNWYKASK SSCIFKRCVS LILDLSLTPH PSHLPKWHES PCGTPEAPGN SIEGFLCKFN FKGMCRPLAL GGPGRVTYTT PFQATTSSLE AVPFASVANV ACGDEAKSET HYFLCNEKTP GIFHWGSSGP LCVSPKFGCS FNNGGCQQDC FEGGDGSFRC GCRPGFRLLD DLVTCASRNP CSSNPCTGGG MCHSVPLSEN YTCRCPSGYQ LDSSQVHCVD IDECQDSPCA QDCVNTLGSF HCECWVGYQP SGPKEEACED VDECAAANSP CAQGCINTDG SFYCSCKEGY IVSGEDSTQC EDIDECSDAR GNPCDSLCFN TDGSFRCGCP PGWELAPNGV FCSRGTVFSE LPARPPQKED NDDRKESTMP PTEMPSSPSG SKDVSNRAQT TGLFVQSDIP TASVPLEIEI PSEVSDVWFE LGTYLPTTSG HSKPTHEDSV SAHSDTDGQN LEHHHHHH.
Safety Data Sheet
Usage
ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
