Catalogue number
PRO-2194
Synonyms
Snail Family Zinc Finger 2, SLUG, Protein Snail Homolog 2, WS2D, Slug Homolog, Zinc Finger Protein (Chicken), Slug (Chicken Homolog), Zinc Finger Protein, Neural Crest Transcription Factor SLUG, Neural Crest Transcription Factor Slug, Snail Homolog 2 (Drosophila), Zinc Finger Protein SNAI2, Snail Homolog 2, SLUGH1, SNAIL2, SLUGH, SNAI2.
Introduction
Snail Family Zinc Finger 2 also known
as SNAI2 is a member of the snail C2H2-type zinc-finger protein family. SNAI2
acts as a transcriptional repressor which binds to E-box motifs and is as well
likely to repress E-cadherin transcription in breast carcinoma. SNAI2 is
implicated in epithelial-mesenchymal transitions furthermore, it has
antiapoptotic activity.
Description
SNAI2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 291 amino acids (1-268 a.a) and having a molecular mass of 32.4kDa.
SNAI2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
SNAI2 protein solution (0.5mg/ml) containing 20mM Tris-HCl Buffer (pH8.0) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 80.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMPRSFLV KKHFNASKKP NYSELDTHTV IISPYLYESY SMPVIPQPEI LSSGAYSPIT VWTTAAPFHA QLPNGLSPLS GYSSSLGRVS PPPPSDTSSK DHSGSESPIS DEEERLQSKL SDPHAIEAEK FQCNLCNKTY STFSGLAKHK QLHCDAQSRK SFSCKYCDKE YVSLGALKMH IRTHTLPCVC KICGKAFSRP WLLQGHIRTH TGEKPFSCPH CNRAFADRSN LRAHLQTHSD VKKYQCKNCS KTFSRMSLLH KHEESGCCVA H
Safety Data Sheet
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
