Catalogue number
PRO-1747
Synonyms
Zinc Ribbon Domain Containing 1, Zinc Ribbon Domain
Containing, 1, HTEX-6, Rpa12, TEX6, ZR14, DNA-Directed RNA Polymerase I Subunit
RPA12, hZR14, RNA Polymerase I Small Specific Subunit Rpa12, tctex-6, Transcription-Associated
Zinc Ribbon Protein, RPA12, Zinc Ribbon Domain-Containing Protein 1.
Introduction
Zinc
Ribbon Domain Containing 1 (ZNRD1) is a protein which shows similarity to the
Saccharomyces cerevisiae Rpa12p subunit of RNA polymerase
I. ZNRD1 contains two potential
zinc-binding motifs and takes part in regulation of cell proliferation. ZNRD1
is involved in cancer and human immunodeficiency virus progression. Alternate
splicing of this gene results in two transcript variants encoding the same
protein. Additional splice variants have been found, but their full-length
sequences have not been determined.
Description
ZNRD1 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 149 amino acids (1-126a.a) and
having a molecular mass of 16.3kDa.ZNRD1 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
ZNRD1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater than 95% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMSVMDLA NTCSSFQSDL DFCSDCGSVL PLPGAQDTVT CIRCGFNINV RDFEGKVVKT SVVFHQLGTA MPMSVEEGPE CQGPVVDRRC PRCGHEGMAY HTRQMRSADE GQTVFYTCTN CKFQEKEDS
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
