Catalogue number
PRO-1886
Synonyms
Natural Cytotoxicity Triggering Receptor 3, LY117, 1C7, Lymphocyte
Antigen 117, Activating Natural Killer Receptor P30, Natural Killer Cell
P30-Related Protein, NK-p30, NKp30, CD337, MALS, Activating NK-A1 Receptor, CD337
Antigen, NKP30.
Introduction
Cytotoxicity
Triggering Receptor 3 also known as NCR3 is a natural cytotoxicity receptor
(NCR) which assists NK cells in the lysis of tumor cells. Moreover, NCR3
interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide
polymorphism in the 5' untranslated region of NCR3 has been related with mild
malaria suceptibility. Three transcript variants encoding various isoforms have
been found for this gene.
Description
NCR3 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 141 amino acids (19-138 a.a) and
having a molecular mass of 15.3kDa.
NCR3 is fused to a 21 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
NCR3 protein solution (0.5mg/ml) containing 20mM Tris-HCl
buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater
than 90% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MLWVSQPPEI RTLEGSSAFL PCSFNASQGR LAIGSVTWFR DEVVPGKEVR NGTPEFRGRL
APLASSRFLH DHQAELHIRD VRGHDASIYV CRVEVLGLGV GTGNGTRLVV EKEHPQLGAG T
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
