Catalogue number
CYT-920
Synonyms
Activin A Receptor Type II-Like 1, ACVRLK1, ALK1, TGF-B
Superfamily Receptor Type I EC 2.7.11.30, TSR-I, ALK-1, HHT2, SKR3
Serine/Threonine-Protein Kinase Receptor R3 Activin A Receptor, Type
II-Like Kinase 1, Activin Receptor-Like Kinase 1, EC 2.7.11, ORW2, HHT.
Introduction
Activin A Receptor Type II-Like 1, also known
as ACVRL1 is a membrane-anchored proteoglycan which his core protein binds TGFf3 and has a short
cytoplasmic domain with no discernible signaling structure. Furthermore, ACVRL1 shares similar domain structures with
other closely related ALK or activin receptor-like kinase proteins which form a
subfamily of receptor serine/threonine kinases.
Description
ACVRL1 produced in Sf9 Insect cells is a single, glycosylated
polypeptide chain containing 103 amino acids (22-118a.a.) and having a
molecular mass of 11.5kDa. (Molecular size on SDS-PAGE will appear at
approximately 18-28kDa).
ACVRL1 is expressed with a 6 amino acid His tag at
C-Terminus and purified by proprietary chromatographic techniques.
Source
Sf9,
Insect cells.
Physical Appearance
Sterile
filtered colorless solution.
Formulation
ACVRL1 protein solution (0.25mg/ml) contains phosphate
buffered saline (pH7.4) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater
than 95.0% as determined by SDS-PAGE.
Amino acid sequence
DPVKPSRGPL VTCTCESPHC KGPTCRGAWC TVVLVREEGR HPQEHRGCGN LHRELCRGRP TEFVNHYCCD SHLCNHNVSL VLEATQPPSE
QPGTDGQ
HHH HHH.
Safety Data Sheet
Usage
ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
