Catalogue number
CYT-1070
Synonyms
MPL Ligand, THCYT1, MPLLG, TPO, ML, Thrombopoietin
Nirs Variant 1, MKCSF, Thrombopoietin, Myeloproliferative Leukemia Virus
Oncogene Ligand, Megakaryocyte Growth and Development Factor, Megakaryocyte
Colony-Stimulating Factor, C-Mpl Ligand, MGDF, Megakaryocyte Stimulating
Factor, Prepro-Thrombopoietin.
Introduction
| Thrombopoietin is a glycoprotein hormone produced mainly by the liver and the kidney which regulates the production of platelets by the bone marrow. TPO stimulates the production as well as differentiation of megakaryocytes, the bone marrow cells which fragment into large numbers of platelets. |
Description
Thrombopoietin Human Recombinant produced in CHO cells has a molecular weight range of 80-90kDa due to glycosylation.
The TPO is purified by proprietary chromatographic techniques.
Source
Chinese Hamster Ovary Cells.
Physical Appearance
Sterile Filtered clear solution.
Formulation
TPO protein solution contains phosphate buffered saline (pH7.4) and 2% albumin.
Stability
Thrombopoietin although stable at room temperature for 1 week, should be stored between 2-8°C.
Purity
Greater than 98% as determined by SDS-PAGE.
Biological Activity
The ED50 as determined by the dose-dependent stimulation of MO7e cells corresponding to a specific activity of 3x105 units/mg.
Safety Data Sheet
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
