Catalogue number
CYT-883
Synonyms
Ciliary
Neurotrophic Factor Receptor, CNTF Receptor Subunit Alpha, CNTFR-Alpha, Ciliary
Neurotrophic Factor Receptor Subunit Alpha, Ciliary neurotrophic factor
receptor subunit alpha, CNTF receptor subunit alpha, CNTFR-alpha.
Introduction
Ciliary Neurotrophic Factor Receptor, also known as CNTFR is a member of
the type I cytokine receptor family. CNTFR binds to CNTF. ?The alpha subunit
provides the receptor specificity. Sole
nucleotide polymorphisms in CNTFR has been associated with variations in muscle
strength, in addition to early onset of eating disorders.
Description
CNTFR Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 341 amino acids (23-342 a.a) and
having a molecular mass of 38.1kDa.
CNTFR is fused to a 21 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered colorless clear solution.
Formulation
CNTFR protein solution (1mg/ml) containing 20mM Tris-HCl
buffer (pH 8.0) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MQRHSPQEAP HVQYERLGSD VTLPCGTANW DAAVTWRVNG TDLAPDLLNG SQLVLHGLEL
GHSGLYACFH RDSWHLRHQV LLHVGLPPRE PVLSCRSNTY PKGFYCSWHL PTPTYIPNTF NVTVLHGSKI
MVCEKDPALK NRCHIRYMHL FSTIKYKVSI SVSNALGHNA TAITFDEFTI VKPDPPENVV ARPVPSNPRR
LEVTWQTPST WPDPESFPLK FFLRYRPLIL DQWQHVELSD GTAHTITDAY AGKEYIIQVA AKDNEIGTWS
DWSVAAHATP WTEEPRHLTT EAQAAETTTS TTSSLAPPPT TKICDPGELG S.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
