Catalogue number
PRO-1884
Synonyms
Haptoglobin-Related Protein, A-259H10.2, Haptoglobin-Related
Locus, HP.
Introduction
Haptoglobin-Related
Protein also known as HPR, is a primate-specific plasma protein related with
apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL) particles
which shown to be a part of the innate immune defense. HPR-bound hemoglobin might
contribute to the biologic activity of the circulating apoL-I/Hprcontaining HDL
particles. HPR is a clinically significant forecaster of recurrence of breast
cancer.
Description
HPR Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 352 amino acids (20-348 a.a) and
having a molecular mass of 39.3kDa.
HPR is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
HPR protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.5), 20% glycerol 1mM DTT and 0.15M NaCl.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater
than 85% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSLYSGNDV TDISDDRFPK PPEIANGYVE HLFRYQCKNY YRLRTEGDGV
YTLNDKKQWI NKAVGDKLPE CEAVCGKPKN PANPVQRILG GHLDAKGSFP WQAKMVSHHN LTTGATLINE
QWLLTTAKNL FLNHSENATA KDIAPTLTLY VGKKQLVEIE KVVLHPNYHQ VDIGLIKLKQ KVLVNERVMP
ICLPSKNYAE VGRVGYVSGW GQSDNFKLTD HLKYVMLPVA DQYDCITHYE GSTCPKWKAP KSPVGVQPIL
NEHTFCVGMS KYQEDTCYGD AGSAFAVHDL EEDTWYAAGI LSFDKSCAVA EYGVYVKVTS IQHWVQKTIA EN
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
