Catalogue number
PRO-1823
Synonyms
Cell Cycle Exit And Neuronal Differentiation 1, BM88, BM88
Antigen, Cell Cycle Exit And Neuronal Differentiation Protein 1.
Introduction
Cell
Cycle Exit And Neuronal Differentiation 1, also known as CEND1, is a
neuron-specific protein. CEND1 take part
in cell cycle control and neuronal differentiation mechanisms during neonatal
SVZ neurogenesis and turn out to be crucial for the transition from neuroblasts
to mature neurons when reaching high levels. The similar protein in pig
enhances neuroblastoma cell differentiation in vitro and involved in neuronal
differentiation in vivo. Multiple pseudogenes have been reported for this gene.
The disease neuroblastoma has been associated with CEND1.
Description
CEND1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 148 amino acids (1-125 a.a) and having a molecular mass of 15.0kDa (molecular size on SDS-PAGE will appear higher).
CEND1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
CEND1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater
than 85% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMESRGKS ASSPKPDTKV PQVTTEAKVP PAADGKAPLT KPSKKEAPAE
KQQPPAAPTT APAKKTSAKA DPALLNNHSN LKPAPTVPSS PDATPEPKGP GDGAEEDEAA SGGPGGRGPW
SCENFNPL
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
