Catalogue number
PRO-2351
Synonyms
C-Type Lectin Domain Family 1 Member B, C-Type
Lectin-Like Receptor 2, CLEC-2, CLEC2, C-Type Lectin Domain Family 1, Member B,
1810061I13Rik, PRO1384, QDED721,
CLEC2B, C-type lectin
domain family 1 member B, C-type lectin-like receptor 2.
Introduction
C-type Lectin Domain Family 1 Member B, also known as CLEC1B. NK-Natural killer cells express multiple calcium-dependent (C-type) lectin-like receptors, for instance CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), which interact with major histocompatibility complex class I molecules and either inhibit or else activate cytotoxicity and cytokine secretion. CLEC1B is a C-type lectin-like receptor which is expressed in myeloid cells as well as in NK cells.
Description
CLEC1B Human Recombinant produced in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 184 amino acids (55-229a.a) and having a molecular mass of 21.8kD (Molecular size on SDS-PAGE will appear at approximately 28-57kDa).
CLEC1B is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Source
Sf9,
Baculovirus cells.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
CLEC1B protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 90.0% as determined by SDS-PAGE.
Amino acid sequence
ADPSVMQRNY
LQGENENRTG TLQQLAKRFC QYVVKQSELK GTFKGHKCSP CDTNWRYYGD SCYGFFRHNL TWEESKQYCT
DMNATLLKID NRNIVEYIKA RTHLIRWVGL SRQKSNEVWK WEDGSVISEN MFEFLEDGKG NMNCAYFHNG
KMHPTFCENK HYLMCERKAG MTKVDQLPHH HHHH.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
