Catalogue number
PRO-2218
Synonyms
Latexin, Endogenous carboxypeptidase inhibitor, ECI, Tissue
carboxypeptidase inhibitor, TCI.
Introduction
Lxn also known as Latexin is a member of the protease inhibitor I47
(latexin) family.? Lxn's function is
hardly reversible, non-competitive, as well as potent inhibitor of CPA1, CPA2
and CPA4. Furthermore, Lxn plays a role in inflammation. Among the diseases
associated with LXN are endocervicitis and listeriosis.
Description
LXN Mouse Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 245 amino acids (1-222 a.a) and
having a molecular mass of 27.9kDa.
LXN is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
LXN protein solution (1mg/ml) containing Phosphate Buffer
Saline (pH7.4), 30% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMEIPPTH YAASRAASVA ENCINYQQGT PHKLFLVQTV QQASKEDIPG
RGHKYHLKFS VEEIIQKQVT VNCTAEVLYP QMGQGSAPEV NFTFEGEIGK NPDEEDNTFY QSLMSLKRPL
EAQDIPDNFG NVSPQMKPVQ HLAWVACGYV MWQNSTEDTW YKMLKIQTVK QVQRNDDFIE LDYTILLHDI ASQEIIPWQM
QVLWHPQYGT KVKHNSRLPK EGQAE.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
