Catalogue number
PRO-2083
Synonyms
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 7, Coiled-Coil-Helix-Coiled-Coil-Helix
Domain-Containing Protein 7, COX23 Cytochrome C Oxidase Assembly Homolog (S.
Cerevisiae), COX23 Cytochrome C Oxidase Assembly Homolog , COX23, Coiled-coil-helix-coiled-coil-helix
domain-containing protein 7.
Introduction
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 7, also known as
CHCHD7 is a newly recognized member of a multifamily of proteins which contains
a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain. The
biological function of CHCHD7 is unknown and the gene has up till now not been
connected with neoplasia. In addition, CHCHD7 & PLAG1 are located
head-to-head about 500 bp apart in 8q12. Molecular analyses of twenty seven
tumors exposed CHCHD7-PLAG1 fusions in three tumors, two of them had t(6;8) and
t(8;15) translocations as a singular anomalies and one a normal karyotype.
Description
CHCHD7 Human Recombinant produced in E.Coli is a single,
non-glycosylated polypeptide chain containing 120 amino acids (1-97 a.a) and
having a molecular mass of 13.9kDa.
CHCHD7 is fused to a 23 amino acid His-tag at N-terminus
& purified by proprietary chromatographic techniques.
Source
E.coli.
Physical Appearance
Sterile Filtered colorless solution.
Formulation
CHCHD7 protein solution (0.25mg/ml) containing 20mM
Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Greater than 90% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMHQTRTG KKTVRMPSVT QRLRDPDINP CLSESDASTR CLDENNYDRE
RCSTYFLRYK NCRRFWNSIV MQRRKNGVKP FMPTAAERDE ILRAVGNMPY.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
