Catalogue number
PRO-1748
Synonyms
Mature T-Cell Proliferation 1, Mature T-Cell Proliferation-1 Type B1, MTCP-1 Type B1, P13MTCP1, Mature T-Cell Proliferation 1 Isoform P13, p8MTCP1, Protein P13 MTCP-1, C6.1B, p13MTCP1.
Introduction
Mature T-Cell Proliferation 1, also known as MTCP1
was recognized by involvement in some t(X;14)
translocations linked with mature T-cell proliferations.
This region has a complex gene structure, with a common promoter and 5' exon
spliced to two dissimilar
sets of 3' exons which encode two different proteins. It represents the upstream 13 kDa protein which
belongs to the TCL1 family. In addition, MTCP1 enhances the phosphorylation and
activation of AKT1 and AKT2. MTCP1 is involved in leukemogenesis. Among the diseases associated with MTCP1 are queensland tick typhus,
and african tick-bite fever.
Description
MTCP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids (1-107a.a) and having a molecular mass of 15.0kDa.
MTCP1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
MTCP1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl ,10% glycerol and 1mM DTT.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please avoid freeze thaw cycles.
Purity
Greater than 95% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSMAGEDVG APPDHLWVHQ EGIYRDEYQR TWVAVVEEET SFLRARVQQI QVPLGDAARP SHLLTSQLPL MWQLYPEERY MDNNSRLWQI QHHLMVRGVQ ELLLKLLPDD
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
