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Biotin - anti mouse CD45RB - Clone HB220

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Biotin - anti mouse CD45RB - Clone HB220

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Biotin - anti mouse CD45RB - Clone HB220

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Biotin - anti Mouse CD45RB - HB220

Reference	Size	Price	Quantity	Add to cart
MO45RBB(V25)	25 μg	70,00 € tax excl.	The minimum purchase order quantity for the product is 1
MO45RBB(V100)	100 μg	145,00 € tax excl.	The minimum purchase order quantity for the product is 1

Reference

Size

Price

Quantity

Add to cart

MO45RBB(V25)

25 μg

70,00 € tax excl.

MO45RBB(V100)

100 μg

145,00 € tax excl.

Product Description

Clone: HB220
Isotype: Rat IgG2a
Tested Applications: Flow Cytometry
Conjugated: Biotin
Concentration: 0.5 mg/ml
Immunogen: Cloned mouse Th2 cell lines
Species Reactivity: Mouse
Storage Buffer: The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
Regulatory Status: RUO
Recommended Usage: CD45RB, clone HB220, is a mAb intended for RUO in the identification of cells that express CD45RB. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 μg/106 cells.
Presentation: Liquid
Storage Instruction: Store in the dark at 2-8 °C

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Large description: CD45RB monoclonal antibody specifically recognizes an exon B-dependent epitope of CD45 lycoprotein, which is found at high density on peripheral B cells, T cytotoxic/suppressor cells, subset of T helper cells, and most thymocytes and at low density on macrophages and dendritic cells.The level of CD45RBB expression appears to decrease as T lymph ocytes progress from naive to memory cells. In addition, subpopulations of CD4+ T cells which express high and low levels of CD45RBB have different cytokine secretion profiles and mediate distinct immunological functions. CD25+ D4+ regulatory T (Treg) lymph ocytes which control intestinal inflammation and autoimmunity express low levels of CD45RBB. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction.

Other names: Ptprc; CD45R; CD45; LCA; Leukocyte common antigen; Ly-5; Lyt-4
GeneID:
Molecular weight: 220 kD