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PURE - anti mouse CD45.1 - Clone A20

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PURE - anti mouse CD45.1 - Clone A20

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PURE - anti Mouse CD45.1 - A20

Reference	Size	Price	Quantity	Add to cart
MO451PU(V50)	50 μg	70,00 € tax excl.	The minimum purchase order quantity for the product is 1
MO451PU(V500)	500 μg	120,00 € tax excl.	The minimum purchase order quantity for the product is 1

Reference

Size

Price

Quantity

Add to cart

MO451PU(V50)

50 μg

70,00 € tax excl.

MO451PU(V500)

500 μg

120,00 € tax excl.

Product Description

Clone: A20
Isotype: Mouse IgG2a
Tested Applications: Flow Cytometry
Conjugated: PURE
Concentration: 0.5 mg/ml
Immunogen: SJL mouse thymocytes and splenocytes
Species Reactivity: Mouse
Storage Buffer: The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
Regulatory Status: RUO
Recommended Usage: CD45.1, clone A20, is a mAb intended for RUO in the identification of cells that express CD45.2. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 μg/106 cells.
Presentation: Liquid
Storage Instruction: Store in the dark at 2-8 °C

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Large description: CD45 (Lukocyte Common Antigen) is foundon all leukocytes of mouse strains expressing the CD45.1 alloantigen (eg, RIII, SJL/J, STS/A, DA). This alloantigen was originally named Ly-5.2, and this was the designation at the time that the antibody was characterized. The designation was later changed from Ly-5.2 to Ly-5.1 to conform with the convention that the .2 alloantigen designations be assigned to the C57BL/6 strain. mAb A20 has been reported not to react with leukocytes of most other mouse strains, which express the CD45.2 alloantigen. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C,respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. The A20 antibody has been reported to inhibit some responses of B cells, from mice expressing the CD45.1 alloantigen, to antigens and LPS.

Other names: Ly-5; Lyt4; CD45R; LCA; Ptprc; Protein tyrosine phosphatase receptor type C
GeneID:
Molecular weight: 180-240 kD