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Biotin - anti mouse CD314 - Clone C7

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Biotin - anti mouse CD314 - Clone C7

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Biotin - anti Mouse CD314 - C7

Reference	Size	Price	Quantity	Add to cart
MO314B(V50)	50 μg	145,00 € tax excl.	The minimum purchase order quantity for the product is 1

Reference

Size

Price

Quantity

Add to cart

MO314B(V50)

50 μg

145,00 € tax excl.

Product Description

Clone: C7
Isotype: Armenian Hamster IgG
Tested Applications: Flow Cytometry
Conjugated: Biotin
Concentration: 0.5 mg/ml
Immunogen: Soluble mouse NKG2D
Species Reactivity: Mouse
Storage Buffer: The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
Regulatory Status: RUO
Recommended Usage: CD314, clone C7, is a mAb intended for RUO in the identification/enumeration of lymph that express CD314. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 μg/106 cells.
Presentation: Liquid
Storage Instruction: Store in the dark at 2-8 °C

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Large description: CD314 is a lectin-like type II transmembrane protein also known as CD314. It is expressed on NK cells, a subset of CD8+ T cells, ?/? T cells and NK1.1+ T cells, as well as in vitro induced LAK cells. NKG2D serves as a stimulatory immunoreceptor to activate NK cells via the non-covalently associated DAP10 or DAP12 adaptor. Several molecules have been identified as the ligands for NKG2D, including minor histocompatibility molecule, H60, UL16-binding protein-like transcript 1 (Mult1, and a family of retinoic acid early transcript 1 (Rae1) in mice, MHC class-I chain-related protein A (MICA), MICB, and UL16-binding proteins (ULBPs) in humans. present in both mice and humans. NKG2D ligands trigger cytokine (IFN-?, GM-CSF, TNF-?, MIP1? and others) and granzyme release from NK cells. The C7 antibody has been reported to block NK cell killing of targets expressing NKG2D ligands and induce redirected lysis.

Other names: CD314
GeneID: 27007
Molecular weight: 27 kD