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Biotin - anti mouse CD25 - Clone PC61

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Biotin - anti mouse CD25 - Clone PC61

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Biotin - anti Mouse CD25 - PC61

Reference	Size	Price	Quantity	Add to cart
MO25B(V25)	25 μg	55,00 € tax excl.	The minimum purchase order quantity for the product is 1
MO25B(V100)	100 μg	145,00 € tax excl.	The minimum purchase order quantity for the product is 1

Reference

Size

Price

Quantity

Add to cart

MO25B(V25)

25 μg

55,00 € tax excl.

MO25B(V100)

100 μg

145,00 € tax excl.

Product Description

Clone: PC61
Isotype: Rat IgG1
Tested Applications: Flow Cytometry
Conjugated: Biotin
Concentration: 0.5 mg/ml
Immunogen: IL-2-dependent cytolytic mouse T-cell clone B6.1
Species Reactivity: Mouse
Storage Buffer: The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
Regulatory Status: RUO
Recommended Usage: CD25, clone PC61, is a mAb intended for RUO in the identification of cells that express CD25. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 μg/106 cells.
Presentation: Liquid

Large description: CD25, the low-affinity IL-2 Receptor α chain (IL-2Rα, p55) expressed on activated T and B lymphocytes from all mouse strains tested. IL-2Rα by itself is not a signaling receptor. However, it can combine with IL-2 Receptor β (CD122) and γc (CD132) chains to form high-affinity, signaling receptor complexes for IL-2. Resting T and B lymphocytes and resting and activated NK cells do not express IL-2Rα. CD25 is transiently expressed at a low level during normal B-cell development in the bone marrow on the CD45R/B220low TdT- sIg- Pre-B/Pre-B-II and CD45R/B220low TdT- sIgM+ sIgD- immature B stages, but not on the CD45R/B220low TdT+ sIg- Pro-B/Pre-B-I stage nor on CD45R/B220high TdT- sIgM+ sIgD+ mature B cells. It is expressed at a higher level during a very early stage of T-cell development in fetal and ***** thymus. Peripheral CD25+CD4+ lymphocytes called regulatory T (Treg) cells are involved in the maintenance of self-tolerance. It has also been reported that dendritic cells express CD25, recognized by mAb 7D4. The PC61 antibody recognizes an epitope of CD25 which is distinct from the IL-2 and from those recognized by mAbs 3C7 and 7D4. It blocks binding of IL-2 to CD25, presumably by inducing a conpresentacionional change in CD25.

Other names: Interleukin-2 receptor alpha chain IL-2RA IL-2Rα Il2ra IL-2R p66
GeneID: 16184
Molecular weight: 55 kD