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Biotin - anti mouse CD169 - Clone 3D6

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Biotin - anti mouse CD169 - Clone 3D6

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Biotin - anti Mouse CD169 - 3D6

Reference	Size	Price	Quantity	Add to cart
MO169B(V25)	25 μg	63,00 € tax excl.	The minimum purchase order quantity for the product is 1
MO169B(V100)	100 μg	104,00 € tax excl.	The minimum purchase order quantity for the product is 1

Reference

Size

Price

Quantity

Add to cart

MO169B(V25)

25 μg

63,00 € tax excl.

MO169B(V100)

100 μg

104,00 € tax excl.

Product Description

Clone: 3D6
Isotype: Rat IgG2a
Tested Applications: Flow Cytometry
Conjugated: Biotin
Concentration: 0.5 mg/ml
Immunogen: Purified Native Sialoadhesin from spleen
Species Reactivity: Mouse
Storage Buffer: The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
Regulatory Status: RUO
Recommended Usage: CD169, clone 3D6, is a mAb intended for RUO in the identification/enumeration of lymph that express CD169. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 μg/106 cells.
Presentation: Liquid
Storage Instruction: Store in the dark at 2-8 °C

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Large description: CD169, also known as Siglec-1 and Sialoadhesin (Sn), is a type I lectin containing 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains). CD169 binds to sialic acids, which can be found on PSGL-1, CD43, CD206, and CD227. By its affinity to ?2, 3-linked sialic acid, it is involved in macrophage binding to different cell types such as granulocytes, monocytes, NK, B, and T cells. CD169 was initially identified as a sialic acid-dependent sheep erythrocyte receptor (SER) on resident bone marrow cells of mice. It has been identified as highly expressed on resident bone marrow macrophages which plays an important role in retention of stem cells in mesenchymal stem cell niche. It is also found on some specific subsets of tissue macrophages in spleen, lymph nodes, bone marrow, liver, colon, lungs, and cancer cells. Evidence suggest that CD169-positive macrophages serve as lymph node-resident APCs to dominate early activation of tumor antigen-specific CD8+ T cells and invariant NK cell.

Other names: Sialic acid binding Ig-like lectin 1 (Siglec-1), Sialoadhesin (Sn)
GeneID: 20612
Molecular weight: 183 kD