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PURE - anti mouse CD154 - Clone MR1

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PURE - anti mouse CD154 - Clone MR1

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PURE - anti Mouse CD154 - MR1

Reference	Size	Price	Quantity	Add to cart
MO154PU(V100)	100 μg	100,00 € tax excl.	The minimum purchase order quantity for the product is 1
MO154PU(V500)	500 μg	220,00 € tax excl.	The minimum purchase order quantity for the product is 1

Reference

Size

Price

Quantity

Add to cart

MO154PU(V100)

100 μg

100,00 € tax excl.

MO154PU(V500)

500 μg

220,00 € tax excl.

Product Description

Clone: MR1
Isotype: Armenian Hamster IgG
Tested Applications: Flow Cytometry
Conjugated: PURE
Concentration: 0.5 mg/ml
Immunogen: Activated mouse Th1 clone D1.6
Species Reactivity: Mouse
Storage Buffer: The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
Regulatory Status: RUO
Recommended Usage: CD154, clone MR1, is a mAb intended for RUO in the identification/enumeration of lymph that express CD154. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 μg/106 cells.
Presentation: Liquid
Storage Instruction: Store in the dark at 2-8 °C

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Large description: CD154 (CD40 Ligand, gp39) is an accessory molecule expressed on activated T helper (CD4+) lymph ocytes. CD154 has also been detected on other types of leukocytes, including CD8+ T cells, medullary thymocytes, activated CD4+ NK-T cells, and human NK cells. CD154 plays an important role in costimulatory interactions between T and B lymph ocytes and between antigen-presenting cells and lymph ocytes, regulating the immune response at multiple levels. MR1 mAb inhibits in vitro activation of B lymph ocytes by T helper cells by blocking interaction of gp39 with CD40. In vitro interactions of T cells and antigen-presenting cells can also be blocked by the MR1 antibody. In vivo treatment with MR1 antibody blocks the development of experimental autoimmune disease, inhibits formation of germinal centers and generation of memory B cells, reduces T-lymph ocyte responses to allogeneic cells and allografts, prevents intrathymic deletion of self-reactive T lymph ocytes, and disrupts antigen-specific T-cell responses.

Other names: CD40 Ligand, gp39
GeneID: 21947
Molecular weight: 39 kD