CD11c clone N418 is specific for CD11c, a 150 kD glycoprotein also known as αX integrin, CR4, and p150. CD11c, a member of the leukointegrin family, is expressed prominently on tissue macrophages and dendritic cells and binds to complement fragment (iC3b), provisional matrix molecules (fibrinogen), and the Ig superfamily cell adhesion molecule, ICAM-1. CD11c has been proposed to function in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T cell proliferation by Langerhans cells2. The N418 epitope is detected only on dendritic cells and is not present on peritoneal macrophages, anti-immunoglobulin induced B lymph oblasts or bulk lymph node cells. The antibody reacts precipitates a 150/90 kDa CD11/CD18 heterodimer. The anti-mouse CD11c mAb N418 blocks CD11c binding to iC3b, ICAM-1, and VCAM-1
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?X integrin, CR4, and p150
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16411
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150 kD
