Reactivity: The monoclonal antibody is directed against the CD7-antigen (3A1-antigen), which is?expressed on human T lymphocytes.The monoclonal antibody reacts with the cells of the T lymphocyte?linage, with the cells of patients with a Lymphocytic Leukaemia of the T lymphocyte origin, and with the?cells of patients with the Sezary Syndrome. Platelets and cells of the B lymphocyte myelocytic and?monocytic lineage are found negative.
Specificity: Anti-CD7, HIT7 was included in the fifth International Workshops on Human Leucocyte?Differentiation Antigens. This antibody reacts with the CD7 antigen, a 40kDa polypeptide. This is the?earliest marker antigen expressed in the T cell lineage and is found on T cell precursors in fetal liver and?thorax prior to thymic colonization and in bone marrow and the thymus. It is also to be found on a small?subpopulation of normal B cells and on malignant B cells.
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gp40, T-cell antigen CD7, GP40, T-cell leukemia antigen, T-cell surface antigen Leu-9, TP49
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