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PURE - anti human CD62L - Clone HI62L

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PURE - anti human CD62L - Clone HI62L

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PURE - anti Human CD62L - HI62L

Reference	Size	Price	Quantity	Add to cart
62LPU-01MG	100 μg	130,00 € tax excl.	The minimum purchase order quantity for the product is 1

Reference

Size

Price

Quantity

Add to cart

62LPU-01MG

100 μg

130,00 € tax excl.

Product Description

Clone: HI62L
Isotype: IgG2a
Tested Applications: FCM
Conjugated: PURE
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Immunogen: Tissue / cell preparation
Species Reactivity: Human
Storage Buffer: The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
Regulatory Status: RUO
Recommended Usage: CD62p, clone HI62P, is a mAb used for the identification of activated platelets, megakaryocytes and endothelial cells. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/106 cells.

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Large description: This antibody reacts with the CD62L-antigen, which mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes and promotes initial tethering and rolling of leukocytes in endothelia. The epitope is expressed at high density on the majority of CD45RA-positive and CD45RO-positive peripheral blood T cells (60-70%) and on a subset of thymocytes that includes the multinegative CD3-negative, CD4-negative, and CD8-negative progenitor cells and the CD45RO-negative presumptive thymic generative lineage. It appears at reduced density and frequency on CD45RA-negative thymocytes, comprised mainly of death-committed cells. The antibody also labels a major subset of peripheral blood B cells and thymic B cells. The antigen is expressed on neutrophils, monocytes, T and B lymphocyte subsets and NK cells. CD62L on neutrophils, but not on lymphocytes, carries the carbohydrate structure sialyl-Lewis X. This carbohydrate is ligand for the selectins P-selectin (CD62P) and E-selectin (CD62E) which can be expressed on endothelial cells, and the interaction of CD62L with these selectins has been argued to play a role in the initial adhesion of neutrophils to endothelium.

Other names: L-Selectin, LAM-1, LECAM-1, Leu-8, MEL-14, TQ-1, CD62 antigen-like family member L, Leukocyte adhesion molecule 1, LAM-1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1,Lymph node homing receptor, TQ1, gp90-MEL
GeneID: 6402
Molecular weight: 76 kDa