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APC - anti human CD49c - Clone VJ1/6

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APC - anti human CD49c - Clone VJ1/6

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APC - anti Human CD49c - VJ1/6

Reference	Size	Price	Quantity	Add to cart
49CA-100T	100 test	420,00 € tax excl.	The minimum purchase order quantity for the product is 1

Reference

Size

Price

Quantity

Add to cart

49CA-100T

100 test

420,00 € tax excl.

Product Description

Clone: VJ1/6
Isotype: IgG1
Tested Applications: FCM
Conjugated: APC
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Immunogen: Integrin alpha 3
Species Reactivity: Human
Storage Buffer: The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
Regulatory Status: RUO
Recommended Usage:

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Large description: This antibody reacts with the CD49c-antigen (VLA-3 alpha-chain or Integrin alpha-3/beta-1) a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. The monoclonal antibody VJ1/6 reacts with ? 3 integrin, a transmembrane glycoprotein which non-covalently associates with integrin ? 1 (CD29) to form the ?3b1 (CD49c/CD29,VLA-3) complex which is proteolytically cleaved into two disulfide linked fragments of 125 kD and 30 kD. CD49c is expressed mostly on endothelial and epithelial cells (basal epidermal layers). It is not expressed on platelets and is expressed weakly on peripheral blood leukocytes. The CD49c/CD29 complex serves as an adhesive receptor for kalinin or epiligrin. This interaction may be important for thymocyte interaction with thymic epithelium. This antibody is suitable for immunohistochemical staining on acetone-fixed frozen tissue sections

Other names: Integrin alpha-3, CD49 antigen-like family member C, FRP-2, Galactoprotein B3, GAPB3, VLA-3 subunit alpha, MSK18, VCA-2; VL3A; VLA3a
GeneID:
Molecular weight: 150 kDa