Reactivity: The monoclonal antibody is directed against the CD4-antigen (T4-antigen),which is?expressed on human peripheral T lymphocytes and 80% of thymocytes. The monoclonal antibody reacts?on a low level with human monocytes and macrophages. The monoclonal antibody does not react with?B-cells, granulocytes and thrombocytes.
Specificity: 60Kd MW lymphocyte surface antigen identified by monoclonal antibodies belonging to the?CD4 cluster and present on 54% of peripheral blood T lymphocytes, 50% of thymocytes and some?malignant cells of T cell origin. Normal B lymphocytes, monocytes or granulocytes do not express?surface CD4 antigen although cytoplasmic expression has been observed in monocytes/macrophages.?The CD4 positive T lymphocyte subpopulation has been characterised functionally as comprising helper?cells active in amplification of immune responses.
Publication references:?
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Acebes-Huerta A. et al. Lenalidomide Induces Immunomodulation in Chronic Lymphocytic Leukemia and Enhances Antitumor Immune Responses Mediated by NK and CD4 T Cells. 2014 Biomed Res Int.?
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182694/
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Huergo-Zapico L et al. Expansion of NK Cells and Reduction of NKG2D Expression in Chronic Lymphocytic Leukemia. Correlation with Progressive Disease. 2014 PLoS One
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186792/
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T4, L3T4, T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-7
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