This antobody is a 407 amino acid nuclear hematopoietic protein of the interferon inducible p200-familiy proteins, and its encoding gene is located at chromosomal band 1q21-22 (23, 24). It is capable of DNA binding and mediating protein–protein interaction, thereby slowing down proliferation, modulating cell survival and promoting differentiation (25). MNDA is expressed in maturating normal and neoplastic myelomonocytic cells, a subset of lymphocytes and some lymphomas but not in other human cells or tissues. Its expression mounts with differentiation, the highest expression shown in mature granulocytes and monocytes (23, 26). MNDA expression has been proven to be diminished on mRNA and protein levels in patients with familial and sporadic MDS (25, 27, 28)
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myeloid cell nuclear differentiation antigen
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4332
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