品牌：List Labs
貨號：172B
品名：List Labs Anthrax Lethal Factor (LF), Recombinant from B. anthracis
中文名：
規(guī)格：1 mg
純度：請參閱CoA
形式：請參閱CoA
儲存溫度：請參閱CoA
描述：
Bacillus anthracis is regarded as a major biological warfare threat. The principal virulence factors are a γ-linked poly-D-glutamic acid (PGA) capsule and a three component exotoxin composed of protective antigen (PA), lethal factor (LF) and edema factor (EF). These proteins act in binary combinations. The complex of PA, the cell binding component, with the LF enzyme, is termed lethal toxin and can cause death. PA and the enzymatic EF together cause skin edema. Secreted PA is cleaved by membrane peptidases. This allows the 63 kDa carboxy terminal fragment to oligomerize to a heptamer or higher. Cleavage of PA is an essential step in exposing the binding sites for EF and LF. The complex enters the cell through endocytosis. PA mediates the transfer of LF and EF to the cytoplasm where these enzymes recognize and alter their targets.
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