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TNF-R2 antibody detects endogenous levels of total TNF-R2. TNF-R2 Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Target	TNF-R2
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Tested Applications	WB, IF/ICC
Recommended dilutions	WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	A synthesized peptide derived from human TNF-R2.
Purification	Affinity Chromatography.
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight	48 kDa
Swiss Prot	P20333
Buffer	Rabbit IgG in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.