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This gene encodes a member of the paired box (PAX) family of transcription factors.The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box.PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation.This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation.Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis.This gene is located at 9p13, which is involved in t (9;14) (p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas.This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas.Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Target	PAX5
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	ELISA, WB, IHC
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E. coli.
Purification	Purified antibody
Isotype	IgG1
Conjugation	Unconjugated
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight	45 kDa
Concentration	1.0 mg/ml
Buffer	PBS with 0.05% sodium azide and 0.5% protein stabilizer.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.