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PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. It functions as an estrogen receptor (ER) selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity and is probably involved in regulating mitochondrial respiration activity and in aging.

Target	PHB2
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Tested Applications	IHC
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Human PHB2.
Purification	Peptide Affinity Purified Rabbit Polyclonal Antibody.
Isotype	IgG
Conjugation	Unconjugated
Specificity	This PHB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from human PHB2.
Storage	Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Swiss Prot	Q99623
Gene Symbol	PHB2
Buffer	PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.