PDX1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this protein are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
Target
PDX1 (p11)
Reactivity
Human
Host
Rabbit
Clonality
Polyclonal
Tested Applications
DB
Recommended dilutions
Optimal dilutions/concentrations should be determined by the end user.
Immunogen
Human PDX1 (phospho-Thr11).
Purification
Purified Rabbit Polyclonal Antibody.
Isotype
IgG
Conjugation
Unconjugated
Specificity
This PDX1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T11 of human PDX1.
Storage
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Swiss Prot
P52945
Buffer
PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.